%0 Journal Article
%T Dichloroacetic acid upregulates apoptosis of ovarian cancer cells by regulating mitochondrial function
%A Chunli Yuan
%A Li Zhou
%A Lianlian Liu
%A Liying Han
%A Ting Zhao
%A Wei Chai
%A Xin Jin
%A Xinxin Guo
%J Archive of "OncoTargets and therapy".
%D 2019
%R 10.2147/OTT.S194329
%X Metabolic reprogramming is a characteristic of tumor cells and is considered a potential therapeutic target. Even under aerobic conditions, tumor cells use glycolysis to produce energy, a phenomenon called the ˇ°Warburg effectˇ±. Pyruvate dehydrogenase kinase 1 (PDK1) is a key factor linking glycolysis and the tricarboxylic acid cycle. Dichloroacetic acid (DCA) reverses the Warburg effect by inhibition of PDK1 to switch cytoplasmic glucose metabolism to mitochondrial oxidative phosphorylation (OXPHOS)
%K DCA
%K glycolysis
%K mitochondrial function
%K glucose
%K metabolism
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419601/