%0 Journal Article
%T Potent in vitro and xenograft antitumor activity of a novel agent, PV-10, against relapsed and refractory neuroblastoma
%A Aru Narendran
%A Chunfen Zhang
%A Lucy Swift
%A Tanya Trippett
%J Archive of "OncoTargets and therapy".
%D 2019
%R 10.2147/OTT.S191478
%X Neuroblastoma is the most common extracranial cancer in children. Although the prognosis for low-risk neuroblastoma patients is good, the 5-year survival rates for high-risk and relapsed patients are low. The poor survival rates for these patients demonstrate the need for novel therapeutic approaches to treat this disease. PV-10 is a sterile 10% solution of Rose Bengal that has previously been shown to induce cell death in a range of adult cancers, providing the rationale for studying the activity of PV-10 against neuroblastoma in preclinical studies
%K neuroblastoma
%K PV-10
%K Rose Bengal
%K novel therapeutics
%K intralesional
%K oncolytic
%K immunotherapy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388978/