%0 Journal Article
%T Follow-up and management of recurrent pregnancy losses due to massive perivillous fibrinoid deposition
%A Alison Migliori
%A Mai He
%A Niharika D Mehta
%A Nisreen S Maari
%J Archive of "Obstetric Medicine".
%D 2018
%R 10.1177/1753495X17710129
%X Massive perivillous fibrinoid deposition is a rare placental pathology associated with significant adverse pregnancy outcome and can recur. We provide a detailed case review of a woman through 10 of her pregnancies, including 8 consecutive pregnancy losses and 2 live births. We also conducted a retrospective chart review of all massive perivillous fibrinoid deposition placenta specimens at our institution over an eight-year period. A total of 42 cases of massive perivillous fibrinoid deposition were identified from 2007 to 2015, yielding an incidence of 0.16%. Recurrence was seen in subsequent pregnancy in eight out of nine (88.9%) cases with more than one specimen. The clinical characteristics, perinatal outcomes and ¦Á-feto protein level of the 42 cases are presented. Also, presented is a review of the literature discussing placental pathology, pathogenetic mechanisms and management of this condition
%K Placenta
%K massive perivillous fibrinoid deposition
%K maternal floor infarction
%K pregnancy loss
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888839/