%0 Journal Article
%T Detection of Cancer Stem Cells in Colorectal Cancer: Histopathological and Immunohistochemical Study
%A Ahmed S. A. Soliman
%A Dina O. Helmy
%A Manal A. Badawi
%A Mona M. Zaki
%A Nour El Hoda S. Ismaiel
%A Walid M. Sharaf
%J Archive of "Open Access Macedonian Journal of Medical Sciences".
%D 2016
%R 10.3889/oamjms.2016.126
%X Growing evidence supports the notion that the onset of tumorigenesis could occur through cancer stem cells (CSCs). These tumour cells show low proliferative rates, high self-renewal capacity, propensity to differentiate into active proliferating tumour cells & resistance to chemoradiotherapy thus, possibly causing local recurrences & metastasis formation. CD44 has been used as a marker to isolate CSCs from colorectal carcinoma (CRC)
%K Cancer stem cells
%K CD44
%K Colorectal carcinoma
%K Metastasis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175496/