%0 Journal Article
%T Role of noise and parametric variation in the dynamics of gene regulatory circuits
%A Mingyang Lu
%A Vivek Kohar
%J Archive of "NPJ Systems Biology and Applications".
%D 2018
%R 10.1038/s41540-018-0076-x
%X Illustration of sRACIPE. a The workflow of sRACIPE. The method integrates two ensemble-based sampling schemes¡ªconstant noise with multiple initial conditions (MIC) and simulated annealing (SA). b Illustration of the stability and basin of attraction using an example of a double-well potential. Upper left: High noise enables frequent transitions between the minima, and the steady-state probability distribution in each well is proportional to the stability of the well. Upper right: Intermediate noise permits a larger number of transitions from the less stable well to the more stable well, and some trajectories are trapped in the more stable well. Bottom left: As the noise is decreased further, the annealing based sampling scheme results in more occurrences of the particles in the more stable well. Bottom right: For low noise cases, the transitions between wells are rare. Thus, each well traps all the particles in its basin of attraction, and the steady-state probability distribution is proportional to the basin width of the well
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218471/