%0 Journal Article
%T Regulation of exocytosis and mitochondrial relocalization by Alpha-synuclein in a mammalian cell model
%A Barbara Baird
%A David Eliezer
%A David Holowka
%A Marcus M. Wilkes
%A Meraj Ramezani
%A Tapojyoti Das
%J Archive of "NPJ Parkinson's Disease".
%D 2019
%R 10.1038/s41531-019-0084-6
%X Structural features of a-syn. a Schematic representation of the a-syn primary sequence delineating the amphipathic membrane-binding domain (orange) and the acidic C-terminal tail (green), and indicating the locations of the NAC domain, helix-1 and helix-2 of the broken-helix state, and the sites of PD and other mutations examined in the manuscript. b Cartoon model of Wt a-syn in an extended helix conformation. The model was generated from RCSB protein data bank entry 1XQ8 by manually converting the non-helical linker between helix-1 and helix-2 to a helical conformation. The sidechains of residues Ala 30 and Val 70 are shown to indicate the location of proline mutations examined in this study. c Wt a-syn in the broken helix conformation (RCSB protein data bank entry 1XQ8) with the sidechains of Ala 30 and Val 70 show
%K Microscopy
%K Cell biology
%K Cellular neuroscience
%K Parkinson's disease
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597712/