%0 Journal Article
%T Genetic fine-mapping of the Iowan SNCA gene triplication in a patient with Parkinson¡¯s disease
%A Anne Lynn S. Chang
%A Birgitt Sch¨¹le
%A Dennis W. Dickson
%A Eli Hatchwell
%A Faria Zafar
%A J. William Langston
%A James W. Tetrud
%A Krisztina K. Johansen
%A Peggy S. Eis
%A Ruksana Azhu Valappil
%A Sam Kim
%J Archive of "NPJ Parkinson's Disease".
%D 2018
%R 10.1038/s41531-018-0054-4
%X SNCA genomic triplication neuropathology. a Gross pathology of midbrain and pons with loss of neuromelanin pigment in both; b alpha-synuclein immunohistochemistry of locus ceruleus with Lewy bodies and bizarre neuronal inclusions; c Numerous Lewy dots in ventral tegmental region of midbrain; d spongiform change in neocortex in temporal and limbic lobes; e CA2 sector of hippocampus with Lewy neurites; f CA2 sector of hippocampus with tau in subset of Lewy neurites; g, h cortical Lewy bodies in temporal neocortex; cortical Lewy bodies and Lewy neurites in temporal neocortex; i hippocampal CA2 neurites; j amygdala Lewy bodies and neurites; k ventral tegmental area Lewy neurites (¡°Lewy dots¡±); l substantia nigra pars compacta Lewy bodies.alpha-synuclein immunohistochemistry (b, c, e, h), phospho alpha-synuclein (i, j, k, l), tau immunohistochemistry (f), hematoxylin and eosin stain (d, g). Bar in b£¿=£¿20 ¦Ìm (applies to c, e, f, g, h, i, j, and k); bar in d and l£¿=£¿50 ¦Ìm; measure bar in a is in m
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003950/