%0 Journal Article
%T Comparisons of gut microbiota profiles in wild-type and gelatinase B/matrix metalloproteinase-9-deficient mice in acute DSS-induced colitis
%A Doris Vandeputte
%A Ghislain Opdenakker
%A Jeroen Raes
%A Jo£¿o Sabino
%A Magali de Bruyn
%A S¨¦verine Vermeire
%J Archive of "NPJ Biofilms and Microbiomes".
%D 2018
%R 10.1038/s41522-018-0059-0
%X Clinical and macroscopic parameters of DSS-induced inflammation in WT and MMP-9-/- mice. a Representation of the acute DSS model. DSS-exposed mice comprised of WT mice (n£¿=£¿10) and MMP-9-/- mice (n£¿=£¿10). Control mice received normal drinking water throughout the experiment (WT mice (n£¿=£¿10), MMP-9-/- mice (n£¿=£¿10)). All groups consisted of five males and five females. b Relative weight loss from the start of the experiment until the time of sacrifice (* day 9). c Absolute weight loss at the time of sacrifice. d Disease activity index including stools, blood, and weight loss at the time of sacrifice. e Colon weight/length (w/l) ratio. f Macroscopic damage score including mesenterial colonic adhesion, hyperemia along the colon, and length of colonic inflammation. Medians with interquartile ranges are shown and Mann¨CWhitney U tests were performed (***p£¿<£¿0.001
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120875/