%0 Journal Article
%T Improved delivery of the anticancer agent citral using BSA nanoparticles and polymeric wafers
%A Anna Evison
%A Benjamin White
%A Eszter Dombi
%A Helen E Townley
%J Archive of "Nanotechnology, Science and Applications".
%D 2017
%R 10.2147/NSA.S148068
%X Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, with a 5-year survival rate of between 30 and 65%. Standard treatment involves surgery, radiation treatment, and chemotherapy. However, there is a high recurrence rate, particularly from locoregional spread. We investigated the use of the natural compound citral (3,7-dimethyl-2,6-octadienal), which can be found in a number of plants, but is particularly abundant in lemon grass (Cymbopogon citratus) oil, for activity against immortalized RMS cells. Significant cancer cell death was seen at concentrations above 150 ¦ÌM citral, and mitochondrial morphological changes were seen after incubation with 10 ¦ÌM citral. However, since citral is a highly volatile molecule, we prepared albumin particles by a desolvation method to encapsulate citral, as a means of stabilization. We then further incorporated the loaded nanoparticles into a biodegradable polyanhydride wafer to generate a slow release system. The wafers were shown to degrade by 50% over the course of 25 days and to release the active compound. We therefore propose the use of the citral-nanoparticle-polymer wafers for implantation into the tumor bed after surgical removal of a sarcoma as a means to control locoregional spread due to any remaining cancerous cells
%K citral
%K nanoparticle
%K wafer
%K biodegradable
%K mitochondria
%K toroidal
%K cancer
%K rhabdomyosarcoma
%K Cymbopogon citratus
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724714/