%0 Journal Article
%T The interaction of transcription factors controls the spatial layout of plant aerial stem cell niches
%A Benoit Landrein
%A Henrik J£¿nsson
%A Julia Deichmann
%A J¨¦r¨¦my Gruel
%A Thomas Hitchcock
%J Archive of "NPJ Systems Biology and Applications".
%D 2018
%R 10.1038/s41540-018-0072-1
%X Expression of pHAM1::YPET-N7 a and pHAM2::YPET-N7 b in representative meristems of different sizes. Meristems were obtained by growing plants on soil, on soil supplied with fertiliser, or on a mixture of soil and sand, leading to meristems of various sizes. Top images show z-projections (sum slices) and bottom images show sections through the centre of the inflorescence meristem. YPET signal is represented using the Fire lookup table of ImageJ. Scale bar: 10£¿¦Ìm. c Schematic of the model: the epidermis controls WUS expression with an IFF-like motif (both inducing and repressing its expression), as introduced in Gruel et al.13 The epidermis also represses the expression of HAM. HAM and WUS monomers can heterodimerize; WUS monomer induces the expression of CLV3 while the heterodimer represses it. Finally, the CLV3 peptide represses the expression of WUS. d Parameter optimisations result in three possible behaviours. The panel presents the expression of WUS, CLV3 and HAM on a colour scale varying from blue (no expression) to green (optimisation target expression) to red (twice the target expression). HAM¨CWUS dimers and WUS monomers are plotted on a relative colour scale varying from blue (minimal concentration) to red (maximal concentration). Additionally the outline of the pocket formed by the HAM¨CWUS dimers is displayed (smaller meristems), in blue are concentrations below the maximal value found in the epidermis and in red are concentrations above this valu
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127332/