%0 Journal Article
%T Mouse Homologue of the Schizophrenia Susceptibility Gene ZNF804A as a Target of Hoxc8
%A Hyun Joo Chung
%A Ji-Yeon Lee
%A Custer C. Deocaris
%A Hyehyun Min
%A Sang Hoon Kim
%A Myoung Hee Kim
%J Journal of Biomedicine and Biotechnology
%D 2010
%I Hindawi Publishing Corporation
%R 10.1155/2010/231708
%X Using a ChIP-cloning technique, we identified a Zinc finger protein 804a (Zfp804a) as one of the putative Hoxc8 downstream target genes. We confirmed binding of Hoxc8 to an intronic region of Zfp804a by ChIP-PCR in F9 cells as well as in mouse embryos. Hoxc8 upregulated Zfp804a mRNA levels and augmented minimal promoter activity in vitro. In E11.5 mouse embryos, Zfp804a and Hoxc8 were coexpressed. Recent genome-wide studies identified Zfp804a (or ZNF804A in humans) as a plausible marker for schizophrenia, leading us to hypothesize that this embryogenic regulatory control might also exert influence in development of complex traits such as psychosis.
%U http://www.hindawi.com/journals/biomed/2010/231708/