%0 Journal Article
%T Tropheryma whipplei Endocarditis: Case Presentation and Review of the Literature
%A Alexander Levendel
%A Brian Chong
%A Katy Lai
%A Michael McGee
%A Stephen Brienesse
%J Archive of "Open Forum Infectious Diseases".
%D 2019
%R 10.1093/ofid/ofy330
%X Whipple¡¯s disease is a rare infective condition, classically presenting with gastrointestinal manifestations. It is increasingly recognized as an important cause of culture-negative endocarditis. We present a case of Whipple¡¯s endocarditis presenting with heart failure. A literature review identified 44 publications documenting 169 patients with Whipple¡¯s endocarditis. The average age was 57.1 years. There is a clear sex predominance, with 85% of cases being male. Presenting symptoms were primarily articular involvement (52%) and heart failure (41%). In the majority of cases, the diagnosis was made on examination of valvular tissue. Preexisting valvular abnormalities were reported in 21%. The aortic valve was most commonly involved, and multiple valves were involved in 64% and 23% of cases, respectively. Antibiotic therapy was widely varied and included a ceftriaxone, trimethoprim, and sulfamethoxazole combination. The average follow-up was 20 months, and mortality was approximately 24%. Physician awareness is paramount in the diagnosis and management of this rare condition
%K endocarditis
%K Tropheryma whippeli
%K Whipple¡¯s disease
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329903/