%0 Journal Article
%T Role of dietary histidine in the prevention of obesity and metabolic syndrome
%A James H OKeefe
%A James J DiNicolantonio
%A Mark F McCarty
%J Archive of "Open Heart".
%D 2018
%R 10.1136/openhrt-2017-000676
%X A recent Chinese supplementation study, in which obese middle-aged women diagnosed with metabolic syndrome received 12 weeks of supplemental histidine (2£¿g, twice daily) or matching placebo, achieved remarkable findings.1 Insulin sensitivity improved significantly in the histidine-supplemented subjects, and this may have been partially attributable to loss of body fat. Body mass index (BMI), waist circumference and body fat declined in the histidine-supplemented group relative to the placebo group; the average fat loss in the histidine group was a robust 2.71£¿kg. Markers of systemic inflammation such as serum tumour necrosis factor-alpha (TNF-¦Á) and interleukin (IL)-6, non-esterified fatty acids and oxidative stress also decreased in the histidine group. Subsequently, precisely parallel findings were reported in female rats rendered obese with a high-fat diet.
%K histidine
%K protein
%K obesity
%K metabolic syndrome
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045700/