%0 Journal Article
%T Blocking CXCLs¨CCXCR2 axis in tumor¨Cstromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment
%A Harold L. Moses
%A Hideaki Ijichi
%A Hiroaki Fujiwara
%A Hiroyuki Isayama
%A Hiroyuki Kato
%A Kazuhiko Koike
%A Keisuke Tateishi
%A Koji Miyabayashi
%A Makoto Sano
%A Ryota Takahashi
%A Takuma Nakatsuka
%A Tomoharu Yamada
%A Yasuo Tanaka
%A Yasuyuki Morishita
%J Archive of "Oncogenesis".
%D 2019
%R 10.1038/s41389-018-0117-8
%X a Top 10 upregulated genes in CAFs after stimulation with conditioned medium (CM) of PDAC cell lines derived from PKF (Ptf1acre/+;LSL-KrasG12D/+;Tgfbr2flox/flox;Cxcr2+/+) mice in the microarray analysis. Cxcl genes are red-colored. b qRT-PCR analysis in CAFs (311f, 545f) after addition of CM from mPanIN cells (PK-CM) or PDAC cells (PKF-CM). Data are means£¿¡À£¿standard error (SE). **p£¿<£¿0.01 compared to the control (C) and (PK-CM). c Invasive activity of PDAC with CM of CAFs with/without CXCR2 inhibitor SB225002. Data are means£¿¡À£¿SE. *p£¿<£¿0.05 compared to the CAF-CM. d Migration of CAFs with CM of mPanIN or PDAC. Data are means£¿¡À£¿SE. *p£¿<£¿0.05, **p£¿<£¿0.01 compared to the control. e Inhibition of CAF migration by CXCR2 inhibitor SB225002. Data are means£¿¡À£¿SE. **p£¿<£¿0.01 compared to the PDAC-C
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338726/