%0 Journal Article
%T Estrogen receptor-¦Á regulation of microRNA-590 targets FAM171A1¡ªa modifier of breast cancer invasiveness
%A M. Radhakrishna Pillai
%A Rahul Sanawar
%A Rakesh Kumar
%A Thankayyan R. Santhoshkumar
%A Vipin Mohan Dan
%J Archive of "Oncogenesis".
%D 2019
%R 10.1038/s41389-018-0113-z
%X a Western blot analysis for FAM171A1 in a panel of cell lines. b, c qRT-PCR analysis of FAM171A1 and ER¦Á in breast cancer cell lines. Unpaired two-tailed t-test; *p£¿=£¿0.033 for FAM171A1; **p£¿=£¿0.002 for ER¦Á. d Boxplots showing mRNA expression of FAM171A1 among TNBC and non-TNBC tumor samples in three Oncomine datasets: TCGA, Curtis, and Kao¡¯s breast; datasets ordered by overexpression Gene Rank-top 10%, a threshold at p value£¿=£¿1E£¿4. e Kaplan¨CMeier survival curve analyses of FAM171A1 in patients with breast cancer in {"type":"entrez-geo","attrs":{"text":"GSE3143","term_id":"3143"}}GSE3143 (n£¿=£¿158) and Breast Invasive Carcinoma TCGA (n£¿=£¿502), datasets stratified based on high (red) and low (blue) in case of {"type":"entrez-geo","attrs":{"text":"GSE3143","term_id":"3143"}}GSE3143 dataset and high (red) and low (green) in case of Breast Invasive Carcinoma TCGA; and *p£¿<£¿0.002, log-rank test. f Overall survival curve of breast cancer patients with hsa-miR590-5p expression in METABRIC (n£¿=£¿1262) and {"type":"entrez-geo","attrs":{"text":"GSE19783","term_id":"19783"}}GSE19783 (n£¿=£¿101), datasets stratified based on high (black) and low (red); log-rank test. All experiments were performed in biological replicates and three technical replicates with similar result
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328622/