%0 Journal Article
%T Subungual Squamous Cell Carcinoma Associated with Long Standing Onychomycosis: Aggressive Surgical Approach with a Favourable Outcome
%A Georgi Tchernev
%A James Patterson
%A Serena Gianfaldoni
%A Stanislav Philipov
%A Torello Lotti
%A Uwe Wollina
%A Yavor Grigorov
%J Archive of "Open Access Macedonian Journal of Medical Sciences".
%D 2017
%R 10.3889/oamjms.2017.116
%X Tumours of the nail bed are rare. Squamous cell carcinoma is the most frequent among them. Chronic infection, chemical or physical trauma/microtrauma, genetic disorders such as congenital ectodermal dysplasia, radiation, tar, arsenic or exposure to minerals, sun exposure, immunosuppression, and previous HPV infection have all been discussed as etiologic factors. The diagnosis is often delayed because of the variety of clinical manifestations, often resembling benign or common infectious processes. Rapidly growing ulcerative lesions should also be considered as potential malignancy. Furthermore, a lack of antifungal or antibacterial treatment response is the most indicative symptom, always requiring subungual biopsy. Early diagnosis is of great importance for therapeutic effectiveness
%K Subungual squamous cell carcinoma
%K nail neoplasms
%K HPV
%K viral wart
%K surgery
%K onychomycosis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535663/