%0 Journal Article
%T 637. ¦¢-Lactam (BL) Antibiotics Promote an IL-1¦Â Response in Patients with Staphylococcus aureus Bacteremia (SaB)
%J Archive of "Open Forum Infectious Diseases".
%D 2018
%R 10.1093/ofid/ofy210.644
%X BL therapy has been associated with reduced SaB duration compared with non-BL therapy. It has been shown that patients with SaB who fail to generate increased serum IL-1¦Â are at risk for prolonged SaB (> 4 days duration), a predictor of mortality. This suggests a major role for the IL-1¦Â host response in prompt clearance of SaB. Furthermore, BL result in reduced peptidoglycan cross-linking, reduced peptidoglycan O-acetylation, and increased alpha-toxin expression, all of which have independently been shown to enhance IL-1¦Â release. This study aims to show that BL therapy results in a more robust IL-1¦Â host response compared with non-BL therapy to explain, in part, more rapid SaB clearance
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6253266/