%0 Journal Article
%T Instrumentation for Time-of-Flight Positron Emission Tomography
%A Eva Pratiwi
%A Hojong Choi
%A Jimin Cheon
%A Jung Yeol Yeom
%A Muhammad Nasir Ullah
%J Archive of "Nuclear Medicine and Molecular Imaging".
%D 2016
%R 10.1007/s13139-016-0401-5
%X Positron emission tomography (PET) is a molecular imaging modality that provides information at the molecular level. This system is composed of radiation detectors to detect incoming coincident annihilation gamma photons emitted from the radiopharmaceutical injected into a patient¡¯s body and uses these data to reconstruct images. A major trend in PET instrumentation is the development of time-of-flight positron emission tomography (ToF-PET). In ToF-PET, the time information (the instant the radiation is detected) is incorporated for image reconstruction. Therefore, precise and accurate timing recording is crucial in ToF-PET. ToF-PET leads to better localization of the annihilation event and thus results in overall improvement in the signal-to-noise ratio (SNR) of the reconstructed image. Several factors affect the timing performance of ToF-PET. In this article, the background, early research and recent advances in ToF-PET instrumentation are presented. Emphasis is placed on the various types of scintillators, photodetectors and electronic circuitry for use in ToF-PET, and their impact on timing resolution is discussed
%K Positron emission tomography
%K Time of flight
%K Instrumentation
%K Timing resolution
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870467/