%0 Journal Article
%T Application of a Small Molecule Radiopharmaceutical Concept to Improve Kinetics
%A Jae Min Jeong
%J Archive of "Nuclear Medicine and Molecular Imaging".
%D 2016
%R 10.1007/s13139-015-0369-6
%X Recently, large molecules or nanoparticles are actively studied as radiopharmaceuticals. However, their kinetics is problematic because of a slow penetration through the capillaries and slow distribution to the target. To improve the kinetics, a two-step targeting method can be applied by using small molecules and very rapid copper-free click reaction. Although this method might have limitations such as internalization of the first targeted conjugate, it will provide high target-to-non-target ratio imaging of radiopharmaceuticals
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870459/