%0 Journal Article
%T Simulation of heterosis in a genome-scale metabolic network provides mechanistic explanations for increased biomass production rates in hybrid plants
%A Ian Small
%A Michael Vacher
%J Archive of "NPJ Systems Biology and Applications".
%D 2019
%R 10.1038/s41540-019-0101-8
%X Selection for inbred populations and heterosis in crosses between them. a Starting with forty initial independent populations (two of which are shown here, the others in Supplementary Fig. S1), we simulated the effect of selection pressure over 50 generations. Each generation contains 500 individuals, from which the top 5% (individuals having the highest biomass production rate) were selected and used as parents for producing the next generation. After 50 generations, the two inbred lines were crossed to produce the F1 and subsequently the F2 populations. The F1 population attained ~34% of the maximum possible biomass production rate. a, b share the same horizontal axis. b The accumulation of homozygous alleles within these populations. After 50 generations the inbreds are homozygous at over 90% of their loci, whereas F1 individuals are 0% homozygous and the F2 individuals 50% homozygous. c Distribution of observed heterosis in 780 simulated crosses between the 40 inbred populations. Here we are defining heterosis as the ratio between the rate of biomass production in the F1 individual and the average of the rates in the two parents (i.e. mid-point heterosis). Values are the mean of 500 F1 or F2 individuals for each cros
%K Computer modelling
%K Systems analysis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639380/