%0 Journal Article
%T Affinity kinetics of leptin-reactive immunoglobulins are associated with plasma leptin and markers of obesity and diabetes
%A Hammadi Ayadi
%A Houda Bouhajja
%A Kamel Jamoussi
%A Mohamed Abid
%A Mouna Mnif-Feki
%A Nicolas Lucas
%A Noura Bougacha-Elleuch
%A Rim Marrakchi
%A Romain Legrand
%A Sergue£¿ O. Fetissov
%A Srini V. Kaveri
%J Archive of "Nutrition & Diabetes".
%D 2018
%R 10.1038/s41387-018-0044-y
%X Plasma levels of leptin-reactive IgG (a). Representative examples of curve fits for the affinity kinetic analysis of a control subject (b), obese (c), obese T2D (d) and lean T2D (e) patients. Affinity kinetics between human leptin and IgG showing: dissociation equilibrium constants (KD, f), association rates (small Ka, g) and dissociation rates (small Kd, h). The data shown are median£¿¡À£¿interquartile range values. f K¨CW test, p£¿=£¿0.084; M¨CW test, £¿p£¿<£¿0.05 obese vs. controls. h K¨CW test, p£¿=£¿0.026; Dunn¡¯s *p£¿<£¿0.05 obese vs. controls; M¨CW test, £¿p£¿<£¿0.05 obese vs. lean T2D, £¿£¿p£¿<£¿0.01 obese vs.ObT2D. Filled circles indicate values statistically identified as outliers. (Controls, n£¿=£¿30; Obese, n£¿=£¿20; ObT2D, n£¿=£¿28 and lean T2D, n£¿=£¿30, error bars: interquartile range).ObT2D, Obese T2D; T2D, type 2 diabete
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966443/