%0 Journal Article
%T Failure of immunosurveillance accelerates aging
%A Guido Kroemer
%A Laurence Zitvogel
%A Maria Perez-Lanzon
%J Archive of "Oncoimmunology".
%D 2019
%R 10.1080/2162402X.2019.1575117
%X Immunosurveillance is generally conceived as a mechanism through which the immune system detects and eliminates (pre-)malignant cells, thus reducing the risk of developing cancer. A recent paper by Ovadya et al. demonstrates that knockout of the gene coding for perforin-1 causes accelerated accumulation of senescent cells in multiple mouse organs, thereby speeding up the aging process. These results suggest that immunosurveillance plays a much broader role in maintaining organismal health than it had been suspected
%K Age-related disease
%K cytotoxic T cells
%K NK cells
%K immunosenescence
%K senescence
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422365/