%0 Journal Article
%T Neuroblastoma patients with high-affinity FCGR2A, -3A and stimulatory KIR 2DS2 treated by long-term infusion of anti-GD2 antibody ch14.18/CHO show higher ADCC levels and improved event-free survival
%A Christian Jensen
%A Holger N. Lode
%A Ina M¨¹ller
%A Karoline Ehlert
%A Madlen J¨¹ttner
%A Maxi Zumpe
%A Nikolai Siebert
%A Sascha Troschke-Meurer
%A Silke Kietz
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2016.1235108
%X Polymorphisms in Fc-gamma-receptor (FCGR) genes as well as killer cell immunoglobulin-like receptor (KIR) and KIR ligand (KIRL) repertoires may influence antitumor effects of monoclonal antibodies (mAb). Here, we systematically analyzed high- and low-affinity FCGR2A and -3A genotypes as well as stimulating and inhibitory KIR/KIRL combinations in 53 neuroblastoma (NB) patients treated by long-term infusion (LTI) of anti-GD2 IgG1 Ab ch14.18/CHO using validated real-time PCR methods
%K Antibody-dependent cell-mediated cytotoxicity (ADCC)
%K ch14.18/CHO
%K Fc-gamma-receptor polymorphisms (FCGR)
%K killer-cell immunoglobulin-like receptor (KIR)
%K KIR ligand (KIRL)
%K neuroblastoma
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139629/