%0 Journal Article
%T Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects
%A Hiroyuki Kubota
%A Hisako Komada
%A Kaoru Ohashi
%A Kazuhiko Sakaguchi
%A Masashi Fujii
%A Shinsuke Uda
%A Shinya Kuroda
%A Wataru Ogawa
%J Archive of "NPJ Systems Biology and Applications".
%D 2018
%R 10.1038/s41540-018-0051-6
%X Concentrations of plasma glucose, serum insulin, and C-peptide during consecutive hyperglycemic and hyperinsulinemic-euglycemic clamps. The mean£¿¡À£¿SD among the subjects for NGT (green, n£¿=£¿50), borderline type (red, n£¿=£¿18), and T2DM (blue, n£¿=£¿53) of experimental (upper 3 panels) and simulation with Model VI (lower 2 panels) time courses are shown. Hyperglycemic clamp (HGC) was performed for 90£¿min and hyperinsulinemic-euglycemic clamp (HEC) for 120£¿min with a 10-min interval. The plasma glucose level is the average value calculated every 5£¿min of the measurements made every 1£¿min, and the serum insulin and C-peptide levels are measured values at sampling time (Methods). Simulation time courses are plotted every 10£¿min. Supplementary Figure S1 and Supplementary Table S1 illustrate the significant difference of concentrations at each time point among the three group
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852153/