%0 Journal Article
%T Immunosuppressive ¦Ã¦Ä T cells foster pancreatic carcinogenesis
%A Guido Kroemer
%A Laura Mondrag¨®n
%A Lorenzo Galluzzi
%J Archive of "Oncoimmunology".
%D 2016
%R 10.1080/2162402X.2016.1237328
%X ¦Ã¦Ä T cells are a subset of CD3+CD4£¿CD8£¿lymphocytes expressing a peculiar T-cell receptor (TCR) that recognizes peptide as well as non-peptide antigens in an MHC-unrestricted fashion.1 A priori, the diversity of ¦Ã¦Ä TCRs would be greater than that of conventional ¦Á¦Â TCRs and B-cell receptors (BCRs) combined, in both mice and humans. However, such a potential diversity is never fully realized. Indeed, ¦Ã¦Ä T cells develop under a very strict endogenous and microenvironmental control, which allows for the emergence of TCRs that are encoded by a single V¦Ã and V¦Ä gene and often exhibit limited, if any, junctional diversity.1 Thus, at least in some aspects, ¦Ã¦Ä T cells are more similar to cells of the innate immune system like natural killer (NK) cells than to ¦Á¦Â T lymphocytes and B cells. Moreover, ¦Ã¦Ä T cells are much less abundant in the peripheral blood than ¦Á¦Â T cells, but are particularly enriched in epithelial tissues like the skin and intestinal tract, where they can account of up to 50% of CD3+ cells.
%K ¦Á¦Â T cells
%K CD4+CD25+FOXP3+ TREG cells
%K chemokine signaling
%K galectin 9
%K IL-10
%K PD-L1
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139650/