%0 Journal Article
%T Do the psychological effects of vagus nerve stimulation partially mediate vagal pain modulation?
%A Eleni Frangos
%A Emily A. Richards
%A M. Catherine Bushnell
%J Archive of "Neurobiology of Pain".
%D 2017
%R 10.1016/j.ynpai.2017.03.002
%X There is preclinical and clinical evidence that vagus nerve stimulation modulates both pain and mood state. Mechanistic studies show brainstem circuitry involved in pain modulation by vagus nerve stimulation, but little is known about possible indirect descending effects of altered mood state on pain perception. This possibility is important, since previous studies have shown that mood state affects pain, particularly the affective dimension (pain unpleasantness). To date, human studies investigating the effects of vagus nerve stimulation on pain perception have not reliably measured psychological factors to determine their role in altered pain perception elicited by vagus nerve stimulation. Thus, it remains unclear how much of a role psychological factors play in vagal pain modulation. Here, we present a rationale for including psychological measures in future vagus nerve stimulation studies on pain
%K ABVN
%K auricular branch of the vagus nerve
%K ACC
%K anterior cingulate cortex
%K DMN
%K default mode network
%K FDA
%K Food and Drug Administration
%K fMRI
%K functional magnetic resonance imaging
%K GABA
%K gamma-aminobutyric acid
%K IL
%K interleukin
%K iVNS
%K invasive vagus nerve stimulation
%K MDD
%K major depressive disorder
%K NTS
%K nucleus tractus solitarius
%K PAG
%K periaqueductal gray
%K STN
%K spinal trigeminal nucleus
%K TNF¦Á
%K tumor necrosis factor alpha
%K VNS
%K vagus nerve stimulation
%K tVNS
%K transcutaneous vagus nerve stimulation Vagus nerve
%K Pain
%K Affect
%K tVNS
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648334/