%0 Journal Article
%T PEGylated Magnetic Nano-Assemblies as Contrast Agents for Effective T2-Weighted MR Imaging
%A Byunghoon Kang
%A Eun-Kyung Lim
%A Hye-young Son
%A Jaewoo Lim
%A Juyeon Jung
%A Seungjoo Haam
%A Taejoon Kang
%A Yong-Min Huh
%A Yuna Choi
%J Archive of "Nanomaterials".
%D 2019
%R 10.3390/nano9030410
%X We designed a high-sensitivity magnetic resonance imaging contrast agent that could be used to diagnose diseases. First, magnetic nanocrystals were synthesized by a thermal decomposition method on an organic solvent to obtain a high magnetism and methoxy poly(ethylene glycol)-poly(lactic acid) as an amphiphilic polymer using the ring-opening polymerization method to stably disperse the magnetic nanocrystals in an aqueous phase. Subsequently, the magnetic nanoclusters simultaneously self-assembled with methoxy poly(ethylene glycol)-poly(lactic acid) using the nano-emulsion method to form magnetic nanoclusters. Because their shape was similar to a raspberry, they were named PEGylated magnetic nano-assemblies. The PEGylated magnetic nano-assemblies were dispersed stably in the aqueous phase with a uniform size of approximately 65¨C70 nm for an extended period (0 days: 68.8 ¡À 5.1 nm, 33 days: 69.2 ¡À 2.0 nm, and 44 days: 63.2 ¡À 5.6). They exhibited both enough of a magnetic resonance (MR) contrast effect and biocompatibility. In an in vivo study, the PEGylated magnetic nano-assemblies provided a high contrast effect for magnetic resonance images for a long time after one treatment, thereby improving the diagnostic visibility of the disease site
%K Magnetic resonance image
%K PEGylated
%K Poly(ethylene glycol)-poly(lactic acid)
%K contrast agent
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473972/