%0 Journal Article
%T Familial Parkinson¡¯s Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2
%A Dongkai Guo
%A Guanghui Wang
%A Haigang Ren
%A Kai Fu
%A Yanfei Wang
%J Archive of "Neuroscience Bulletin".
%D 2017
%R 10.1007/s12264-017-0196-0
%X Omi is involved in the instability of L166P. A Immunoblots of lysates of N2a cells transfected with equal amounts of Flag-DJ-1 or Flag-L166P construct for 36 h and using the indicated antibodies. B Ratios of Flag-DJ-1 or Flag-L166P relative to ¦Á-tubulin from (A) from densitometric analysis Data are from three independent experiments (mean ¡À SEM; *P < 0.05; ns, no statistical significance, one-way ANOVA). C Immunoblots of lysates of H1299 cells co-transfected with Flag-DJ-1 or Flag-L166P and HA, HA-Omi or HA-S276C for 36 h as indicated. D Ratios of Flag-DJ-1 or Flag-L166P relative to ¦Á-tubulin from (C) from densitometric analysis. Data from three independent experiments (mean ¡À SEM, *P < 0.05; ns, no statistical significance, one-way ANOVA
%K Parkinson¡¯s disease
%K DJ-1
%K L166P
%K Instability
%K Omi/HtrA2
%K Cleavage
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725392/