%0 Journal Article %T Familial Parkinson¡¯s Disease-Associated L166P Mutant DJ-1 is Cleaved by Mitochondrial Serine Protease Omi/HtrA2 %A Dongkai Guo %A Guanghui Wang %A Haigang Ren %A Kai Fu %A Yanfei Wang %J Archive of "Neuroscience Bulletin". %D 2017 %R 10.1007/s12264-017-0196-0 %X Omi is involved in the instability of L166P. A Immunoblots of lysates of N2a cells transfected with equal amounts of Flag-DJ-1 or Flag-L166P construct for 36 h and using the indicated antibodies. B Ratios of Flag-DJ-1 or Flag-L166P relative to ¦Á-tubulin from (A) from densitometric analysis Data are from three independent experiments (mean ¡À SEM; *P < 0.05; ns, no statistical significance, one-way ANOVA). C Immunoblots of lysates of H1299 cells co-transfected with Flag-DJ-1 or Flag-L166P and HA, HA-Omi or HA-S276C for 36 h as indicated. D Ratios of Flag-DJ-1 or Flag-L166P relative to ¦Á-tubulin from (C) from densitometric analysis. Data from three independent experiments (mean ¡À SEM, *P < 0.05; ns, no statistical significance, one-way ANOVA %K Parkinson¡¯s disease %K DJ-1 %K L166P %K Instability %K Omi/HtrA2 %K Cleavage %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725392/