%0 Journal Article %T Non-obstructive cardiovascular disease: a£¿new challenge for invasive cardiology? %A J. J. Piek %A M. E. Wittekoek %J Archive of "Netherlands Heart Journal". %D 2018 %R 10.1007/s12471-017-1062-4 %X Cardiovascular disease is the leading cause of death worldwide, and coronary artery disease (CAD) is the most common type of heart disease. Up to 20¨C30% of patients presenting with chest discomfort demonstrate no signs of obstructive CAD. In the field of invasive cardiology more than 50% of the patients undergoing coronary angiography for non-acute chest pain have normal or near normal coronary arteries [1]. Non-obstructive CAD in acute coronary syndromes has attracted much attention because of the relatively high incidence of adverse cardiovascular events if not appropriately diagnosed and treated [2] %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758453/