%0 Journal Article
%T The expanding role of the Ehmt2/G9a complex in neurodevelopment
%A Jonathan B. Olsen
%A Steven J. Deimling
%A Vincent Tropepe
%J Archive of "Neurogenesis".
%D 2017
%R 10.1080/23262133.2017.1316888
%X Epigenetic regulators play a crucial role in neurodevelopment. One such epigenetic complex, Ehmt1/2 (G9a/GLP), is essential for repressing gene transcription by methylating H3K9 in a highly tissue- and temporal-specific manner. Recently, data has emerged suggesting that this complex plays additional roles in regulating the activity of numerous other non-histone proteins. While much is known about the downstream effects of Ehmt1/2 function, evidence is only beginning to come to light suggesting the control of Ehmt1/2 function may be, at least in part, due to context-dependent binding partners. Here we review emerging roles for the Ehmt1/2 complex suggesting that it may play a much larger role than previously recognized, and discuss binding partners that we and others have recently characterized which act to coordinate its activity during early neurodevelopment
%K brain
%K chromatin
%K development
%K Ehmt1
%K epigenetics
%K G9a/Ehmt2
%K neurogenesis
%K retina
%K Znf644
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449175/