%0 Journal Article
%T Synthesis of protein-coated biocompatible methotrexate-loaded PLA-PEG-PLA nanoparticles for breast cancer treatment
%A Manal Alaamery
%A Salam Massadeh
%A Saqer Alarifi
%A Shahad Bawazeer
%A Shatha Al-Qatanani
%A Yusra Alyafee
%J Archive of "Nano Reviews & Experiments".
%D 2016
%R 10.3402/nano.v7.31996
%X PLA-PEG-PLA triblock polymer nanoparticles are promising tools for targeted dug delivery. The main aim in designing polymeric nanoparticles for drug delivery is achieving a controlled and targeted release of a specific drug at the therapeutically optimal rate and choosing a suitable preparation method to encapsulate the drug efficiently, which depends mainly on the nature of the drug (hydrophilic or hydrophobic). In this study, methotrexate (MTX)-loaded nanoparticles were prepared by the double emulsion method
%K PEG
%K PLA
%K biodegradable nanoparticles
%K particle size
%K encapsulation efficiency
%K double emulsion method
%K poly(vinyl alcohol)
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919641/