%0 Journal Article
%T The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene
%A Godfrey D Pearlson
%A Henry R Kranzler
%A Hongyu Zhao
%A Joel Gelernter
%A Krishna T Patel
%A Lindsay A Farrer
%A Qian Wang
%A Renato Polimanti
%A Shashwath A Meda
%J Archive of "Neuropsychopharmacology".
%D 2017
%R 10.1038/npp.2016.153
%X To identify genetic mechanisms involved in the interplay of risky sexual behaviors (RSBs) and alcohol dependence (AD), we conducted genome-wide gene-by-AD (GW-GxAD) analyses of RSB in 3924 alcohol-exposed and sexually experienced subjects. RSBs were defined as a score based on lifetime experiences of unprotected sex and multiple sexual partners. Diagnosis of lifetime AD was defined by DSM-IV criteria. To follow-up the genetic findings, functional magnetic resonance imaging analyses were conducted in an independent sample. A trans-population genome-wide significant signal was identified in LHPP (rs34997829; z=£¿5.573, p=2.51 ¡Á 10£¿8) in the GxAD analysis that also showed associations in the AD-stratified association analysis (AD z=£¿2.032 and non-AD z=4.903). The clinical relevance of the result was confirmed by the significant interaction between LHPP rs34997829 and AD with respect to self-reported sexually transmitted disease (STD; z=£¿2.809, p=4.97 ¡Á 10£¿3). The neuroimaging follow-up analysis of LHPP rs34997829 showed reduced power of the left superior frontal gyrus (t=£¿3.386, p=9.56 ¡Á 10£¿4) and increased power at the right amygdala (t=3.287, p=1.33 ¡Á 10£¿3) in the resting amplitude of low frequency fluctuations analysis; and reduced activation of the anterior cingulate region (t=£¿2.961, p=3.69 ¡Á 10£¿3) in the monetary incentive delay task. In conclusion, LHPP locus is associated to AD¨CRSB interaction; and with brain circuitries previously implicated in the inhibition of risky behavior and impulsiveness, emotional regulation, and impulse control/error monitoring. Thus, LHPP is a strong candidate to influence RSB and STD risk in the context of AD
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240175/