%0 Journal Article %T Cardamonin induces ROS-mediated G2/M phase arrest and apoptosis through inhibition of NF-¦ĘB pathway in nasopharyngeal carcinoma %A Bian Wu %A Bo Huang %A Chensu Yang %A Gang Wu %A Haibo Zhang %A Jing Huang %A Kunyu Yang %A Xiaoshu Zhou %A Yong Li %A You Qin %A Yuting Li %J Archive of "Cell Death & Disease". %D 2017 %R 10.1038/cddis.2017.407 %X Cardamonin has been demonstrated to have an inhibitory effect in many cancers, but its underlying mechanism remains elusive. Here, we studied, for the first time, the mechanism of cardamonin-induced nasopharyngeal carcinoma cell death both in vitro and in vivo. In our study, we showed that cardamonin inhibited cancer cell growth by inducing G2/M phase cell cycle arrest and apoptosis via accumulation of ROS. NF-¦ĘB activation was involved in breaking cellular redox homeostasis. Therefore, our results provided new insight into the mechanism of the antitumor effect of cardamonin, supporting cardamonin as a prospective therapeutic drug in nasopharyngeal carcinoma by modulating intracellular redox balance %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596588/