%0 Journal Article
%T Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways
%A Abdulaziz Alkhateeb
%A Abdulhadi A. Alamodi
%A Denis Selimovic
%A Emad Kandil
%A Erin B. Taylor
%A Matthias Hannig
%A Mohamed Hassan
%A Paul L. Friedlander
%A Simeon Santourlidis
%A Siraj M. El Jamal
%A Sofie Y. Hassan
%A Srinivasan Vijaykumar
%A Youssef Haikel
%A Zakaria Y. Abd Elmageed
%J Archive of "Cell Division".
%D 2016
%R 10.1186/s13008-016-0023-4
%X Tumor response to immunotherapy is the consequence of a concerted crosstalk between cytokines and effector cells. Interferon gamma (IFN¦Ã) is one of the common cytokines coordinating tumor immune response and the associated biological consequences. Although the role of IFN¦Ã in the modulation of tumor immunity has been widely documented, the mechanisms regulating IFN¦Ã-induced cell death, during the course of immune therapy, is not described in detail
%K HNSCC
%K IDO
%K HO-1
%K FN-¦Ã
%K JAK
%K STAT1
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969639/