%0 Journal Article
%T MiR-873-5p acts as an epigenetic regulator in early stages of liver fibrosis and cirrhosis
%A Agust¨ªn F. Fern¨¢ndez
%A Ana M. Aransay
%A Ander Arbelaiz
%A Carmen Berasain
%A David Fern¨¢ndez-Ramos
%A Erica Villa
%A Fernando Lopitz-Otsoa
%A Imanol Zubiete-Franco
%A Javier Crespo
%A Jesus M. Banales
%A Jorge Sim¨®n
%A Jos¨¦ Luis Lav¨ªn
%A Jos¨¦ M. Mato
%A Juan Anguita
%A Luc¨ªa Barbier-Torres
%A Mario F. Fraga
%A Marta Varela-Rey
%A Mar¨ªa J. Perugorria
%A Mar¨ªa L. Mart¨ªnez-Chantar
%A Matias A. Avila
%A Naiara Beraza
%A Nicol¨¢s Navasa
%A Pablo Fern¨¢ndez-Tussy
%A Paula Iruzibieta
%A Shelly C. Lu
%A Teresa C. Delgado
%A Virginia Guti¨¦rrez-de-Juan
%J Archive of "Cell Death & Disease".
%D 2018
%R 10.1038/s41419-018-1014-y
%X (a) Luciferase reporter assay of Gnmt 3£¿UTR expression in hepatocytes transfected with mimic-miR-873-5p (N£¿=£¿8). (b) GNMT and miR-873-5p expression at mRNA and protein levels in primary hepatocyte after mimic-miR-873-5p transfection. Gnmt-miR-873-5p expression and correlation and WB analysis of GNMT at different time points of BDL (N£¿=£¿3) (c) and in Mdr2WT and Mdr2-/- mice at different ages (3,4,9,12,17 months each column and 3¡ø, 4¨‹, 9£¿, 12¡ñ, and 17¡ö months in the correlation panel) (N£¿=£¿3) (d). Densitometry analyses of WB are shown in Supp. Fig. 1B, D, E. Data normalized as fold change vs. control. Error bars represent the means£¿¡À£¿SEM. Statistical significance was determined by the Student¡¯s t-test or ANOVA when more than two groups were compared. p£¿<£¿0.05*; p£¿<£¿0.01**; p£¿<£¿0.001**
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148053/