%0 Journal Article
%T Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart
%A Anyun Feng
%A Chi Zhang
%A Hong Yang
%A Lechu Yu
%A Sundong Lin
%A Xiaoqing Yan
%A Xiufei Lin
%A Xuemian Lu
%J Archive of "Cell Death & Disease".
%D 2018
%R 10.1038/s41419-018-0307-5
%X HFD/ STZ-induced type 2 diabetic and age-matched mice received FGF21 treatment for 4 months. Then, mice were killed and the hearts were isolated. Cardiac hypertrophy was evaluated by examining the ratio of heart weight to tibia length (HW/BW, a) and the expression of hypertrophic markers including cardiac ANP (b), BNP (c), and ¦Â-MHC (d). Myocardium structure was examined by H&E staining (e). Fibrosis was evaluated by measuring collagen content by Sirius-red staining (f, g). Data are presented as means£¿¡À£¿SD, n£¿=£¿8/group. *P£¿<£¿0.05 vs. the control (Con) group; #P£¿<£¿0.05 vs. the diabetic (DM) grou
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833682/