%0 Journal Article
%T Simultaneous inhibition of PI3K¦Á and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer
%A Bobo Wang
%A Chunhao Yang
%A Cun Tan
%A Jian Ding
%A Linghua Meng
%A Xi Zhang
%A Xian Li
%A Xueling Liu
%A Yi Chen
%A Yiming Sun
%A Yinglei Gao
%A Yuxiang Wang
%J Archive of "Cancer Biology & Medicine".
%D 2019
%R 10.20892/j.issn.2095-3941.2018.0361
%X Activating KRAS mutations are the most common drivers in the development of non-small cell lung cancer (NSCLC). However, unsuccess of treatment by direct inhibition of KRAS has been proven. Deregulation of PI3K signaling plays an important role in tumorigenesis and drug resistance in NSCLC. The activity of PI3K¦Á-selective inhibition against KRAS-mutated NSCLC remains largely unknown
%K PI3K¦Á
%K CDK4/6
%K KRAS
%K NSCLC
%K CYH33
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528459/