%0 Journal Article
%T Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy
%A Ang Li
%A Caixia Qin
%A Chun-Hong Chen
%A Gang Duan
%A Jian-Chiuan Li
%A Jiangxia Ni
%A Ke Xiang
%A Kuili Tian
%A Xing Sun
%A Xu Cao
%A Xue Deng
%A Yanshan Fang
%A Yongjia Duan
%J Archive of "Cell Death & Disease".
%D 2018
%R 10.1038/s41419-018-1022-y
%X a, b qPCR analysis of the mRNA levels of Parkin and PINK1 in human 293T cells (a) and primary mouse neurons infected with wild-type hTDP-43 (b). c¨Ce The endogenous mouse Parkin mRNA (c) and protein (d) levels of the cortical neurons derived from the hTDP-43Q331K mice are decreased compared to the non-transgenic sibling controls. Non-Tg non-transgenics, hTDP-43 transgenic human TDP-43, mTDP-43 endogenous mouse TDP-43. Parkin protein levels are normalized to Actin and plotted as percentage to controls in (e). Data are shown as means£¿¡À£¿SEM; n£¿=£¿3¨C5; *p£¿<£¿0.05; ns not significant; Student¡¯s t-tes
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148241/