%0 Journal Article
%T RB1CC1-enhanced autophagy facilitates PSCs activation and pancreatic fibrogenesis in chronic pancreatitis
%A Bei Sun
%A Feng-Yu Tian
%A Gang Wang
%A Guang-Quan Zhang
%A Hong-Ze Chen
%A Ji-Sheng Hu
%A Le Li
%A Shang-Ha Pan
%A Xin-Jian Lv
%A Xue-Wei Bai
%A Yi-Long Li
%A Yue Yuan
%J Archive of "Cell Death & Disease".
%D 2018
%R 10.1038/s41419-018-0980-4
%X a, b The heatmap and volcano plots showed that 433 genes were changed in activated PSCs compared with quiescent PSCs (fold change ¡Ý2 or ¡Ü0.5, p£¿¡Ü£¿0.05). c Top ten upregulated genes were listed and RB1CC1 was significantly elevated. d, e The expressions of RB1CC1 protein and mRNA were explored in quiescent and activated PSCs (Bars£¿=£¿500¦Ìm). f Western blot analyses were detected to determine the expressions of RB1CC1, ¦Á-SMA, Fibronectin, Collagen I, and Collagen III in quiescent and TGF-¦Â-treated PSCs. GAPDH served as the internal control. g, h Gene classification and gene function enrichment analysis of differentially expressed genes were performed (*p£¿<£¿0.05 and **p£¿<£¿0.01
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147947/