%0 Journal Article
%T Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis
%A Keizo Takenaga
%A Miho Akimoto
%A Riruke Maruyama
%A Yasunari Kawabata
%A Yoshitsugu Tajima
%J Archive of "Cell Death & Disease".
%D 2018
%R 10.1038/s41419-018-0851-z
%X a, b Cell cycle progression of MIAPaCa-2 cells. The cells treated with solvent (DMSO) alone, 50£¿¦ÌM and 100£¿¦ÌM AdipoRon for 24£¿h were subjected to flow cytometric analysis. c Survival of MIAPaCa-2 cells and HPAEpiC cells. The cells were treated with various concentrations of AdipoRon for 40£¿h. d Survival of human pancreatic cancer cell lines. The cells were treated with various concentrations of AdipoRon for 6 days. e qRT-PCR analysis of the knockdown of AdipoR1 and AdipoR2 expression. f Effect of the knockdown of AdipoR1 and AdipoR2 expression on the survival of MIAPaCa-2 cells treated with solvent alone (V) or 100£¿¦ÌM AdipoRon for 40£¿h. For c¨Cf, error bars represent standard deviation. *P£¿<£¿0.05, **P£¿<£¿0.001 by ANOVA test. ns not significan
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056513/