%0 Journal Article
%T The role of osteopontin in the progression of solid organ tumour
%A Aurelie Pac Soo
%A Azeem Alam
%A Daqing Ma
%A Hailin Zhao
%A Jiang Cui
%A Jianteng Gu
%A Ka Chun Suen
%A Qian Chen
%A Shiori Eguchi
%J Archive of "Cell Death & Disease".
%D 2018
%R 10.1038/s41419-018-0391-6
%X a The schematic representation of the location of OPN on human chromosome 4.OPN is at location 4q22.1. Genes encompassed within a 600£¿kb region on chromosome 4 encodes several noncollagenous bone and dentin proteins including OPN, bone sialoprotein(BSP), dentin matrix protein I (DMPI) and dentin sialophosphoportin (DSPP). All of them are classified as small intergrin-binding ligand N-linked glycoprotein (SIBLING) family proteins. b The signalling pathway of osteopontin. Osteopontin binds integrin ¦Á4¦Â1 which causes degradation of phospharylated inhibitor of nuclear factor kappa-B kinase subunit beta (IKK¦Â). Inhibitor of nuclear transcription factor kappa-B (I¦ÊB¦Á) and nuclear transcription factor kappa-B (NF-¦ÊB; p50 and p65) are both freed following this process. I¦ÊB¦Á is degraded by the ubiquitination pathway, while NF-¦ÊB enters the cell nucleus where it is phosphorylated and it enhances the expression of pro-survival genes. Moreover, upon binding of osteopontin to integrin ¦Á4¦Â1, phosphorylated IKK¦Â causes inactivation of Forkhead box O3 (FOXO3A). Active FOXO3A is important in decreasing the expression of anti-survival genes such as BIM, BAK and BAX which cause caspase activation and cell apoptosis via mitochondrion and release of cytochrome c. Activation of OPN mediate a diverse range of cellular function, including cell survival/ proliferation, cell-cycle progression, cell migration, endothelial mesenchymal transition, T cell activation, cytokine production, fibrosis, angiogenesis and bone calcification and mineralisation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834520/