%0 Journal Article
%T BRAF Non-V600E Mutated Metastatic Colorectal Cancer in a Young Patient: Discussion from a Case Report
%A H¨Śl¨¨ne Senellart
%A Jean-Luc Raoul
%A Jonathan Dauve
%A Judith Raimbourg
%A Laure Moisset
%A Mich¨¨le Boisdron-Celle
%A Sandrine Hiret
%J Archive of "Case Reports in Oncology".
%D 2019
%R 10.1159/000500857
%X We report the case of a 32-year-old man with a caecal adenocarcinoma with major lymph node extension and peritoneal carcinomatosis, presenting a BRAF-K601E mutation. A triplet (5FU plus oxaliplatin plus irinotecan) combination with bevacizumab achieved tumor control but the disease progressed immediately after cessation and the patient died 8 months after the diagnosis. A short review of BRAF non-V600E mutations shows that outcome and clinical features depend on the mutation
%K Metastatic colorectal cancer
%K BRAF mutation
%K Prognosis
%K Molecular characterization
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587192/