%0 Journal Article
%T Interleukin 10-Mediated Response and Correlated Anemia in a Patient with Advanced Non-Small Cell Lung Carcinoma
%A Cherian Verghese
%A Christine S. Cassidy
%A F. Charles Brunicardi
%A Jesse D. Kelso
%A John Nemunaitis
%A Joseph R. Duff
%A Khalil Choucair
%A Lance Dworkin
%A Martin Oft
%A Mary T. Albrethsen
%A Mushtaq Ashraf
%J Archive of "Case Reports in Oncology".
%D 2019
%R 10.1159/000499704
%X Anemia in cancer patients is associated with poor quality of life, reduced response to therapy, and decreased overall survival. We describe a case of a 56-year old woman with advanced metastatic non-small cell lung carcinoma who demonstrated marked response to a novel combinational immunotherapy approach involving a long-acting PEGylated construct of recombinant human Interleukin-10 with Nivolumab, an anti-PD-L1 checkpoint inhibitor. While on treatment, the patient developed severe anemia and hyper-ferritinemia requiring RBC transfusion support. Here we discuss a possible novel immune mechanism of IL10-mediated anemia in correlation with tumor response
%K Anemia
%K Combined immunotherapy
%K Clinical trial
%K Hyper-ferritinemia
%K Tumor response correlate
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489092/