%0 Journal Article
%T Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death
%A Amanda Tomie Ouchida
%A Ayaz Najafov
%A Dimitry Ofengeim
%A Jiefei Geng
%A Junying Yuan
%A Qiang Yu
%A Xiaoxiao Sun
%A Yingbo Li
%J Archive of "Cell Death & Disease".
%D 2018
%R 10.1038/s41419-017-0170-9
%X a Outline of high-throughput screen of cytotoxicity of 12,640 compounds with or without AC220 in ES-2 cells. b Left panel: Fold cell survival data for the screened compounds with (y-axis) or without (x-axis) AC220, with respect to untreated control. Right panel: Student¡¯s t test with respect to untreated control showing the most statistically significant hits. TAK-165 was discovered among the top 45 hits that did not induce cell death alone, but induced cell death in combination with AC220. c TAK-165 (Mubritinib) chemical structure. d Dose-response curve of TAK-165 alone and in combination with AC220 in ES-2 cells. ES-2 cells were treated with TAK-165 at indicated concentrations and AC220 at 2£¿¦ÌM for 24£¿h. Viability was determined using CellTiter-Glo£¿ Luminescent assay (n£¿=£¿3). Bars: Mean£¿¡À£¿SD. *p£¿<£¿0.05; **p£¿<£¿0.01; ***p£¿<£¿0.00
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833862/