%0 Journal Article
%T The Contribution of MMP-7 Genotypes to Colorectal Cancer Susceptibility in Taiwan
%A CHENG-NAN WU
%A CHIA-WEN TSAI
%A CHUN-KAI FU
%A HSIN-TING LI
%A JEN-SHENG PEI
%A MING-HSIEN WU
%A SHIOU-TING YEN
%A TE-CHENG YUEH
%A WEN-SHIN CHANG
%A YI-LIANG LAI
%A YI-MIN LEE
%A YI-WEN HUNG
%J Archive of "Cancer Genomics & Proteomics".
%D 2018
%R 10.21873/cgp.20079
%X Background/Aim: Matrix metalloproteinases (MMPs) play important roles in inflammation and carcinogenesis, but the genotypic role of MMP-7 has never been investigated in colorectal cancer (CRC) among the Taiwanese. Therefore, in this study we aimed to evaluate the contribution of MMP-7 genotypes to the risk of CRC in Taiwan. Materials and Methods: In this case-control study, MMP-7 A-181G and C-153T promoter genotypes were determined and their association with CRC risk were investigated among 362 CRC patients and 362 age- and gender-matched healthy controls. In addition, the interaction of MMP-7 genotypes and personal behaviors were also examined. Results: The percentages of variant AG and GG for MMP-7 A-181G genotypes were 10.5% and 1.7% in the CRC group and 11.9% and 2.2% in the control group, respectively (p for trend=0.7145). The allelic frequency distribution analysis showed that the variant G allele of MMP-7 A-181G conferred a slight but non-significant decreased CRC susceptibility to the wild-type C allele (odds ratio (OR)=0.86, 95% confidence interval (CI)=0.64-1.31, p=0.37). Taiwanese all harbour the CC genotype at MMP-7 C-153T. As for the gene¨Clifestyle interaction, there were no obvious joint effects of MMP-7 A-181G genotype on the risk of CRC among ever smoker, alcohol drinker, non-smoker or non-drinker subgroups. No statistically significant correlation was observed between MMP-7 A-181G genotypic distributions and age, gender, tumor size, location or metastasis status. Conclusion: The genotypes of MMP-7 A-181G may play an indirect role in determining personal susceptibility to CRC and prognosis. The further genotyping work on MMP-7 and other genes (such as other MMPs, oncogenes and tumor suppression genes) on CRC susceptibility and prognosis, should be taken into consideration spontaneously in the precision medicine era
%K Colorectal cancer
%K genotype
%K MMP-7
%K polymorphism
%K Taiwan
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971013/