%0 Journal Article
%T Sonodynamic therapy inhibits palmitate-induced beta cell dysfunction via PINK1/Parkin-dependent mitophagy
%A He Li
%A Rongguo Xiong
%A Tian Guo
%A Tianyang Liu
%A Xianna Liu
%A Ye Tian
%A Yun Sun
%A Zhen Tian
%A Zhiguo Zhang
%A Zhitao Li
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1695-x
%X a Cell viability did not significantly change in beta cells incubated with 0.25¨C4£¿mmol/l ALA for 24£¿h. n£¿=£¿6. *P£¿<£¿0.05, ** P£¿<£¿0.01, ***P£¿<£¿0.001 compared to 0£¿mmol/l groups. b, c Accumulation of ALA-PpIX in beta cells reached peaks at the timepoint of 9£¿h and at the concentration of 1£¿mmol/l ALA. Fluorescence of ALA-PpIX was detected using fluorescence spectrophotometer and normalized to cell population. n£¿=£¿6. ***P£¿<£¿0.001 compared to 1£¿mmol/l groups. d Change of cell viability after 24£¿h post ALA-SDT is shown. Cells were preincubated with 1£¿mmol/l ALA for 9£¿h, then SDT was performed. n£¿=£¿6. * P£¿<£¿0.05, **P£¿<£¿0.01, ***P£¿<£¿0.001 compared to 0£¿W/cm2 groups. Bars£¿=£¿Mean£¿¡À£¿SEM. ALA 5-aminolevulinic acid, PpIX protoporphyrin IX, SDT sonodynamic therap
%K Mitophagy
%K Type 2 diabetes
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560035/