%0 Journal Article
%T Aberrant NFATc1 signaling counteracts TGF¦Â-mediated growth arrest and apoptosis induction in pancreatic cancer progression
%A Elisabeth Hessmann
%A Geske E. Schmidt
%A Marie C. Hasselluhn
%A Steven A. Johnsen
%A Volker Ellenrieder
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1682-2
%X a Hematoxylin and eosin (HE) and immunohistochemical of NKC p48 mice representing different age groups corresponding to different stages of PDAC development (¡Á400, scale bar: 100£¿¦Ìm). b HE stainings (¡Á200, scale bar: 100£¿¦Ìm) certify established PDAC of three individual NKC p48 mice. Western blot analysis of the indicated proteins upon TGF¦Â treatment (10£¿ng/ml) in primary PDAC cells derived from respective NKC p48 mice (NKC cells). c Immunofluorescence demonstrating TGF¦Â-mediated translocation of receptor Smads (Smad2/3) into nuclei of primary PDAC cells (¡Á400, scale bar: 25£¿¦Ìm). d Wound healing assay (n£¿=£¿4) and e invasion assay in the presence and absence of TGF¦Â (n£¿=£¿3
%K Pancreatic cancer
%K Translational research
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554303/