%0 Journal Article
%T Blockade of CTLA-4 and Tim-3 pathways induces fetal loss with altered cytokine profiles by decidual CD4+T cells
%A Chunqin Chen
%A Dajin Li
%A Fengyun Sun
%A Jinfeng Qian
%A Meirong Du
%A Mengdie Li
%A Min Yu
%A Mingyan Wang
%A Rui Zhu
%A Songcun Wang
%A Xingxing Zang
%A Yunyun Li
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-018-1251-0
%X a The weight of pregnant CBA/J females treated with isotype IgG, anti-CTLA-4, anti-Tim-3 antibody, both antibodies i.p. at doses of 500, 250, and 250£¿mg at days 4.5, 6.5, and 8.5, respectively. b The number of live fetuses per uterus from pregnant CBA/J females following treatment with the indicated blocking antibodies. c¨Ce Quantification of flow cytometric analysis of cytokines production and transcription factors expression by dCD4+T cells from pregnant CBA/J female mice following treatment with the indicated blocking antibodies. Data represented the mean£¿¡À£¿standard error of the mean (SEM) of n£¿=£¿6¨C10mice per group and were representative of four independent analyses. *P£¿<£¿0.05, **P£¿<£¿0.01, ***P£¿<£¿0.001, compared with the control group. #P£¿<£¿0.05, ##P£¿<£¿0.01, ###P£¿<£¿0.001, compared with the group of anti-CTLA-4 and anti-Tim-
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325160/