%0 Journal Article
%T Inhibition of SIRT2 limits tumour angiogenesis via inactivation of the STAT3/VEGFA signalling pathway
%A Fuqing Hu
%A Geng Li
%A Guihua Wang
%A Junbo Hu
%A Qi Wu
%A Xi Yang
%A Xuelai Luo
%A Xuling Sun
%A Yaqi Chen
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-018-1260-z
%X a, b Analysis of SIRT2 levels in CRC tumour tissues compared to those in normal samples using Oncomine databases. *P£¿<£¿0.05. c Analysis of SIRT2 protein levels in 12 paired CRC samples and adjacent normal tissues. d Quantification of the protein levels of SIRT2 in 12 paired CRC samples and adjacent normal tissues. N: normal, T: tumour, **P£¿<£¿0.01. e Immunohistochemistry (IHC) staining of SIRT2 in CRC tumour tissues and adjacent normal tissues (n£¿=£¿46). f Vertical scatter plots showing that the IHC score for SIRT2 in the CRC tissue was significantly higher than that in the adjacent normal tissue. ***P£¿<£¿0.001. g SIRT2 levels in different TNM stage patients from {"type":"entrez-geo","attrs":{"text":"GSE24551","term_id":"24551"}}GSE24551. *P£¿<£¿0.05. h Kaplan¨CMeier analysis showing that the high expression of SIRT2 is related to poor prognosis in CRC from {"type":"entrez-geo","attrs":{"text":"GSE24551","term_id":"24551"}}GSE24551. P£¿=£¿0.022
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315023/