%0 Journal Article
%T Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development
%A Baochi Liu
%A Bingxue Shang
%A Changshun Shao
%A Chenchang Xu
%A Keli Liu
%A Lin Song
%A Luowei Wang
%A Qianwen Shang
%A Qing Li
%A Rui Liu
%A Xiaodong Chen
%A Xiaoren Zhang
%A Yanan Li
%A Yanyan Han
%A Yin Huang
%A Ying Wang
%A Yongjing Chen
%A Yufang Shi
%A Yunpeng Chu
%A Zheng Gong
%A Zhiyuan Zheng
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1630-1
%X a Schematic representation of the experimental procedures using CCl4-induced liver fibrosis followed by BMT in a mouse model. b Flow cytometric analysis for the expression of CD25 and CD44 on thymocyte for DN1¨CDN4 stages of the T-cell development in the thymus on day 28 after CD45.1 BMT through the hepatic portal vein. c Flow cytometric analysis for the expression of CD4 and CD8 in thymocytes for the DP and SP stages of T-cell development, on day 28 after CD45.1 BMT. d Flow cytometric analysis for the expression of CD4 and CD8 on PBMCs for CD4+ and CD8+ T cells in peripheral blood on day 28 after CD45.1 BMT. The results are presented as mean£¿¡À£¿S.E.M. Statistical significance was determined by Student¡¯s t test. Significance between samples is indicated in the figures as follows: *P£¿<£¿0.05; **P£¿<£¿0.0
%K Bone marrow transplantation
%K T cells
%K Stem-cell differentiation
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549170/